La hipertensión arterial en animales de laboratorio
José Luis Molina MartÃnez, Leticia Béquer Mendoza, Tahiry Gómez Hernández, Vicente José Hernández Moreno, Cindy Freire Gómez, Daisy Pérez MartÃnez
Resumen
Las Ciencias Médicas y Biológicas requieren, prioritariamente, que la investigación y la experimentación sean desarrolladas sobre organismos completos (los modelos animales). Su utilización ha permitido desarrollar innumerables ensayos preclÃnicos para evaluar los mecanismos patógenos y terapéuticos de diversas enfermedades, asà como el estudio de las causas, naturaleza y cura de múltiples desórdenes de la salud humana. En este trabajo se muestra una panorámica general de los biomodelos de hipertensión arterial donde se describen: conceptos, caracterÃsticas, origen, importancia, utilidad y procedimientos experimentales durante su fase de inducción. También se pondera la justificación de los biomodelos empleados en los estudios preclÃnicos de esta enfermedad. De igual forma, se describen los antecedentes para medir las alteraciones, las técnicas y los métodos directos e indirectos de medición de la presión arterial, la cual fue provocada experimentalmente en los animales de laboratorio para realizar los estudios de hipertensión humana.
Palabras clave
experimentación animal; modelos animales; hipertensión arterial; métodos; presión arterial; rata; animales de laboratorio; fisiopatologÃa
Este artÃculo está licenciado bajo la licencia
Creative Commons Reconocimiento-NoComercial 4.0 Internacional .
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