Carcinoma de células de Merkel: a propósito de un caso
José Ramón Rodriguez Morales, Milagros GarcÃa Rivero
Resumen
El carcinoma de células de Merkel es un tumor poco frecuente, con un curso evolutivo muy agresivo que con frecuencia origina recidivas locorregionales y metástasis. Se asienta predominantemente en zonas fotoexpuestas en pacientes ancianos. Su incidencia se ha cuadriplicado en las últimas décadas debido al envejecimiento de la población y a un mayor diagnóstico, gracias al uso de técnicas inmunohistoquÃmicas. La patogénesis del carcinoma de células de Merkel no está precisada, pero la radiación ultravioleta, la inmunosupresión y la presencia del poliomavirus en el genoma del tumor parecen desempeñar un papel fundamental en el desarrollo de esta neoplasia. El objetivo de este artÃculo es presentar un caso clÃnico de la historia natural de este infrecuente tumor cutáneo, a la vez que detallar aspectos histológicos e inmunohistoquÃmicos necesarios para su diagnóstico y estadificación, por su importante trascendencia en el pronóstico de estos pacientes.
Palabras clave
carcinoma de células de Merkel/cirugÃa
Este artÃculo está licenciado bajo la licencia
Creative Commons Reconocimiento-NoComercial 4.0 Internacional .
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